Do you want to be a senior member of a dynamic research department focusing on making genetic discoveries and translating them for drug discovery? Then you might be the new Principal Scientist in statistical genomics we are looking for at the Novo Nordisk Research Centre Oxford (NNRCO).As our new Principal scientist in statistical genomics, you will join the Department of Genetics to lead projects focusing on integrating human genetics data with other ‘omics data and clinical data to identify new drug targets for cardiometabolic diseases.About Novo Nordisk Research Centre Oxford (NNRCO)NNRCO is our new translational research institute focused on target discovery across the broad spectrum of cardiometabolic disease. We aim to combine the very best of academia, biotech and big pharma, fusing a deep understanding of human genetics, an agile, creative and collaborative culture and drug development. NNRCO will be a world-leading research site focused on asking the big and difficult questions and delivering high impact science.You can read more about NNRCO at: https://www.novonordisk.com/research-and-development/science-and-innovation/global-r-and-d-centres/novo-nordisk-research-centre-oxford.htmlAbout the departmentYou will be part of our Department of Genetics led by Sr. Director, Joanna Howson PhD, which will consist of Specialists, Research Scientists, and Postdocs. The focus of this Department is to use data science and human genetics to identify new drug targets, through a range of approaches e.g. high-throughput genetic discovery screens; Mendelian Randomization; pLoF variant screens and precision medicine approaches relevant to type 2 diabetes, non-alcoholic steatohepatitis (NASH) and cardiometabolic traits.The positionWe offer you an exciting position as a senior member of our Genetics department where you will have the opportunity to have an impact in a department which is currently developing rapidly both organisationally and scientifically. In this position, you will work on state-of-the-art projects in human genetic-driven drug discovery for cardiometabolic diseases. Responsibilities include, but are not limited to: initiating your own projects to identify novel drug targets and developing collaborations with academia and relevant businesses to aid this endeavour; acting as a scientific role model within the team to support more junior members in design, execution and interpretation of analysis; acting as a subject-matter expert and provide genetics expertise across the company.In extension, you will have a broad range of collaborators, ranging from other statistical geneticists, computational biologists, to clinicians and external partners. You will also work closely with the leader of the department to introduce new methods, platforms and data sets. We welcome candidates with a good team ethic, who pay close attention to detail, enjoy a fast paced, dynamic environment where creative intellectual independence is actively encouraged. Most importantly, you must be highly motivated by the opportunity to work with human genetics in the early stages of the drug discovery process. The successful candidate will be a key contributor in the group, and we are open to shaping the role to best fit your personal development and competencies in statistical genetics. QualificationsYou have a PhD in a relevant field e.g. statistical genetics, genetic epidemiology or computational genetics and considerable relevant experience post PhD either in academia or a drug discovery setting. You are expected to have in-depth understanding of human genetic data e.g. genome-wide association studies (GWAS) and translating these findings. Ideal candidates will also have experience of analysing and evaluating ‘omics data such as transcriptomics/proteomics/metabolomics and integration of these data to elucidate causal genes and pathways. A good understanding of statistical concepts, experience of manipulating and managing large datasets and strong computational skills including in statistical packages e.g. python, R, perl, bash would be highly desirable. A background in cardiometabolic trait research (e.g. T2D, renal, coronary artery disease, liver disease) would be an advantage.You will be expected to work well both independently designing and driving the direction of projects, as well as collaboratively as part of a team alongside other inter-disciplinary colleagues in the project team and across NNRCO departments. You show a positive “can-do” attitude, are flexible, open to new ideas and are results oriented. The job requires proficiency in English and excellent communication and collaboration skills.Salary range: GBP 72,000-95,000 yearlyWorking at Novo NordiskAt Novo Nordisk, we use our skills, dedication and ambition to help people with diabetes. We offer the chance to be part of a truly global work place, where passion and engagement are met with opportunities for professional and personal development.ContactFor more information, please contact recruitment partner Nana Nielsen at (+45)30776105 or Jo Howson by email: zjhw@novonordisk.comDeadline23rd July 2020

Job: Physicist - Nuclear MedicineLocation: Bupa Cromwell Hospital, Kensington, London Hours: Permanent, 37.5 hours per weekSalary: £44,500 - £52,000 per annum dependent on experienceReference: R1057252Opening date: 10th JuneClosing date: 10th JulyA bit about usBupa is one of the most well-known and respected healthcare businesses in the world, because what we do matters. From our contact centres to our care homes; health and dental centres to our state-of-the-art hospitals across all four corners of the globe, every part of our operations are dedicated to our purpose of helping people live longer, healthier, happier lives. We pride ourselves on working with brilliant people who put our customers at the heart of everything they do.We’re an internationally recognised hospital located in the heart of Kensington, London. At the Cromwell Hospital we’re committed to providing the highest quality healthcare for our patients. We’re one of the preferred health care providers for leading consultants and for both international and local patients alike. We are continuously investing in standards and the technology to keep us at the forefront of clinical advancement.What you'll be doingThe post holder will actively participate in all aspects of Medical Physics support to Nuclear Medicine, radionuclide therapy services and general radiation protection issues within the hospital environment.What’s a typical day?As the Physicist you’ll maintain the Nuclear Medicine quality assurance programme. This includes undertaking routine quality control checks, measurements and participating in the commissioning of equipment associated with Nuclear Medicine and PET CT.You’ll participate in all aspects of the radionuclide therapy service, contribute to research and development activities and act as radiation protection supervisor (RPS) for the radionuclide therapy service, as well as ensuring compliance to standards in respect of all legislative requirementsYou’ll also contribute to the introduction of new, improved and optimised methods, techniques and service improvements utilising best available evidence, national guidance, results from research and development, undertake complex Nuclear Medicine calculations and image processing as required and actively participate with any inspection or audit.Who we’re looking for?Degree in Physical Science/Engineering or equivalentMasters Degree in Medical Physics or equivalentRegistration as a Clinical Scientist (essential)Managerial experience (desirable)Evidence on ongoing career developmentHCPC Clinical Scientist registration (Desirable)Experience of delivering radionuclide therapiesExperience/training in radiation safetyDiagnostic radiology radiation protection experienceRadionuclide therapy Dosimetry calculationsKnowledge of the use of open and sealed radioactive sourcesAwareness of relevant radiation legislation.To view our benefits, please visit: https://careers.bupa.co.uk/our-roles/nurses/cromwell-hospital/What’s it like to work here?As you’ll already know, we want people to ‘love working here’, so much so that’s it’s at the top of our agenda and something you’ll hear a lot about here at Bupa. We offer our people a great range of benefits, many of which are flexible and can be tailored to suit what’s most important to you. We’re a healthcare company so there’s a huge focus on our people’s health and wellbeing, supported by a healthy work-life balance and workplaces which are friendly, appealing spaces to support you to be at your best.We’re an inclusive organisation that celebrates diversity and welcomes everyone – all talents and backgrounds. Bupa strives to make sure that every applicant is assessed solely on the basis of personal merit and qualifications, regardless of gender, sexual orientation, pregnancy or maternity, marital or civil partner status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability or age. If you’d like to learn more, please contact Louise Griffiths, Senior Specialist Recruiter, on 07714 073 450 or louise.griffiths@bupa.com

Research Associate in Literary Activism (Kenya) The Department of English is looking to appoint a Research Associate who will be, working on the ERC-funded Starting Grant ‘Literary Activism in Sub-Saharan Africa: Commons, Publics and Networks of Practice', led by PI Professor Madhu Krishnan. The project explores everyday encounters with and participation in literary activism (defined both as the act of opening spaces for literary expression and the more explicit intersection of literary engagement and socio-political activism) to develop new understandings of social, political and cultural life in contemporary Africa. Using literary, historical and ethnographic methods, it covers case studies in Kenya, Cameroon, Nigeria, Uganda and Côte d’Ivoire. Over the course of 48 months, the postholder will work with the PI to manage and coordinate the Kenya-based case study. Responsibilities will include field-based and desk research, participation in regular team meetings, contributing to ongoing ethics reporting, organising field-based workshops with key project interlocutors and contributing to project outputs. The Research Associate will also continue to develop their own publication profile and will receive appropriate mentoring and training throughout. The person appointed as Research Associate to the project will need to have secured a PhD degree in a related area of literary studies (including the sociology of literature) with a focus on African literature, even if the formal award of the degree has not yet been made. Please note the role is open ended with fixed funding for 48 months. We can accept applications from overseas applicants requiring sponsorship to work in the UK (providing all sponsorship conditions are met). Timescale of appointment: Start date: 4 January 2021 Short-listed candidates will be notified on or around 17th July and will be asked to submit example of written work by 24th July. Candidates will also be asked to give a 10 min presentation at the interview Anticipated interview date: 6-7 August 2020 Cut-off date for submission of applications: Friday 10 July 2020 Contact for informal enquiries:Professor Madhu Krishnan (madhu.krishnan@bristol.ac.uk)Ms J Kinney (jane.kinney@bristol.ac.uk) Tel. +44 (0)117 331 7982 We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

Research Associate in Literary Activism (Nigeria) The Department of English is looking to appoint a Research Associate who will be, working on the ERC-funded Starting Grant ‘Literary Activism in Sub-Saharan Africa: Commons, Publics and Networks of Practice', led by PI Professor Madhu Krishnan. The project explores everyday encounters with and participation in literary activism (defined both as the act of opening spaces for literary expression and the more explicit intersection of literary engagement and socio-political activism) to develop new understandings of social, political and cultural life in contemporary Africa. Using literary, historical and ethnographic methods, it covers case studies in Kenya, Cameroon, Nigeria, Uganda and Côte d’Ivoire. Over the course of 36 months, the postholder will work with the PI to manage and coordinate the Nigeria-based case study. Responsibilities will include field-based and desk research, participation in regular team meetings, contributing to ongoing ethics reporting, organising field-based workshops with key project interlocutors and contributing to project outputs. The Research Associate will also continue to develop their own publication profile and will receive appropriate mentoring and training throughout. The person appointed as Research Associate to the project will need to have secured a PhD degree in a related area of literary studies (including the sociology of literature) with a focus on African literature, even if the formal award of the degree has not yet been made. Please note the role is open ended with fixed funding for 36 months. We can accept applications from overseas applicants requiring sponsorship to work in the UK (providing all sponsorship conditions are met). Timescale of appointment: Start date: 4 January 2021 Short-listed candidates will be notified on or around 17th July and will be asked to submit example of written work by 24th July. Candidates will also be asked to give a 10 min presentation at the interview Anticipated interview date: 6-7 August 2020 Cut-off date for submission of applications: Friday 10 July 2020 Contact for informal enquiries:Professor Madhu Krishnan (madhu.krishnan@bristol.ac.uk)Ms J Kinney (jane.kinney@bristol.ac.uk) Tel. +44 (0)117 331 7982 We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

We seek an enthusiastic and highly motivated researcher to help design and fabricate a nanoelectromechanical relay-based processor. This is an exciting opportunity to be part of an international project to develop energy-efficient, high-temperature capable electronics for use in emerging paradigms such as the Internet of Things (IoT) and more-electric aircraft. You will work within a team at the University of Bristol and collaborate closely with our partners in the project, including a global semiconductor company, a leading European foundry, and academia, to produce large-scale integrated circuits. Your main tasks will be to design, fabricate and characterise nanoelectromechanical relay-based circuits and functional blocks using ground-breaking nano relay designs that we have produced in the past [1,2]. This work will involve revising and optimising fabrication processes, materials and device designs, and developing new circuits using these devices. The research activities to be carried out require a very thorough grounding in NEMS/MEMS, and the ideal candidate will have experience of working within a cleanroom for nanofabrication and using relevant software tools for design. Applicants should generally have a PhD in MEMS, NEMS, Electrical and Electronic Engineering, Physics, photonics or a related field, but applications from candidates who are about to graduate with a PhD, or who have equivalent experience instead, are welcome. In this post you will be part of the Microelectronics Research Group, and work closely with the PI, Dr. Dinesh Pamunuwa. This appointment represents an opportunity for a committed and motivated researcher to work at a premier British University in collaboration with a glittering array of partners, and establish a track record in a very novel area of semiconductor electronics. You will be exposed to the latest industry practices in design, fabrication and assembly, and have the freedom to innovate. A successful outcome to the project will see demonstration of the first ever nanoelectromechanical relay-based FPGA and very likely result in further opportunities. We understand and appreciate the uncertainties around the lockdown caused by Covid-19, especially for international applicants, for any questions please contact Dr. Pamunuwa (dinesh.pamunuwa@bristol.ac.uk). We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

A postdoctoral research associate position is available in the School of Chemistry at the University of Bristol. The research associate will work under the supervision of Dr Beatrice Collins and Professor Jonathan Clayden. The position is funded by the Leverhulme Trust and is available from the 1st October 2020, with funding for 36 months. The research project involves the development of a new class of autonomous rotary molecular motor driven by biocatalytic processes. The proposed motors will exhibit continuous directional rotation about a carbon–carbon single bond driven by a chemical fuel. Enzymes will be used to mediate concurrent opposing stereoselective redox processes, setting up a non-equilibrium steady state and driving constant dynamic conformational rotation. A range of analytical, mechanistic, and computational methods will be employed to analyse the out-of-equilibrium behaviour of the system and to confirm the molecular-level directional motion. Successful motors will be integrated into more complex supramolecular systems, amplifying the controlled motion at the single molecule level into measurable effects at the macroscopic scale. We are looking for a motivated and enthusiastic researcher, with excellent organizational and communication skills. The successful candidate will hold (or be working towards) a PhD in organic chemistry. While previous experience in the field of artificial molecular machines is not required, experience in modern synthetic chemistry, including the design and execution of multi-step syntheses, is essential. Experience in the field of biocatalysis is also desirable. For informal enquiries, please contact Dr Beatrice Collins (bs.lefanucollins@bristol.ac.uk) or Professor Jonathan Clayden (j.clayden@bristol.ac.uk). We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.