leeds  |   £33,797

research fellow in structural molecular biology are you an ambitious researcher looking for your next challenge? do you have an established background in structural molecular biology? do you want to further your career in one of the uks leading research-intensive universities? we are looking for a highly motivated postdoctoral research fellow to join a team of researchers investigating the structural basis of hypertrophic cardiomyopathy, an inherited heart disease that affects more than 1 in 500 people. most mutations resulting in disease are found in either β-cardiac myosin heavy chain or cardiac myosin-binding protein-c (cmybp-c) yet the link between mutation and disease outcome is poorly characterised. by use of an integrative structural biology approach this research project will unravel structural-functional relationships between β-cardiac myosin and cmybp-c and the impact of disease mutation on those relationships. the project will use a combination of electron microscopy (negative-stain and cryo), structural mass spectrometry, biochemistry, biophysics, molecular modelling and cell biology methods. you should have a phd (or be close to completion) in biology, biochemistry, biophysics or a related discipline. you should have experience in the analysis of protein structure, dynamics and protein-protein interactions using either structural mass spectrometry methods (e.g. native mass spectrometry, chemical crosslinking, covalent footprinting and/or hydrogen-deuterium exchange), and/or cryo-electron microscopy, and complementary biophysical methods (e.g. circular dichroism, sds-page). you should also have experience in protein production from bacterial and, insect or/and mammalian cells. you will be based in the laboratory of dr charlie scarff (bhf intermediate fellow) and will work closely with collaborators at leeds (dr james ault, dr sarah harris and prof. michelle peckham), across the uk and internationally (prof. howard white, evms and prof. donald winkelmann, rutgers). you will join the vibrant astbury centre community and benefit from the world-leading facilities we have in the astbury biostructure laboratory (two titan krios microscopes) and faculty of biological sciences (dedicated hdx-ms system, uhmr q-exactive and orbitrap exploris). to explore the post further or for any queries you may have, please contact: doctor charlie scarff bhf jacqueline murray coomber fellow, email: c.a.scarff@leeds.ac.uk

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  oxford  |   £55,750

the department of physics is seeking an exceptionally talented head of technical services. this is a strategic role to lead the strategic direction of the key technical facilities of the department (including mechanical and electronic design and workshops), and to work closely with academics and facility leaders in ensuring that the technical resources of the department are efficiently resourced, deployed and developed to continue to support the world-leading science of the department, and to meet new and evolving challenges. the successful candidate will lead technical teams of around 40 fte, and be responsible for excellence in technical services supporting a department with income and expenditure in excess of £50m per annum. applicants should possess a degree qualification, have demonstrable experience in leading a high-tech engineering group, proven management and leadership of a diverse technical team as well as experience in project engineering and project management. previous experience of working in the university sector or a large diverse public sector environment will be an advantage, as will experience of change management and an interest in science. please direct enquiries about the role to simon probert simon.probert@physics.ox.ac.uk only applications received before midday 1st june 2021 can be considered. you will be required to upload a supporting statement, cv and details of two referees as part of your online application.

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  london  |   £38,366

description : job title: backend software developer - senior level salary range: competitive (dependent on experience) permanent position reporting to the cto location: city of london (close to moorgate station) no. more. paper. receipts! we're building the world's first ai optimisation platform to optimise and evolve generic software, such as ai systems and mobile apps, allowing for smart optimisation to be carried out at a scale never before achieved. we are looking for a talented developer with a passion for distributed system and microservices who is excited at the opportunity to be involved with everything between feature planning, implementation, testing and architecture of a best in class system.our engineering team are deeply curious and phenomenal problem solvers. we are building a revolutionary platform that is on the cutting edge of research and technology. as an engineering team we all work very closely with all parts of the business including legal, finance, sales and other software. we don’t believe in working in silos and make sure people are mixed up, starting with where you physically sit at our headquarters in city of london. there is no dark corner just with engineers! projects: kafka, rabbitmq messaging framework integration docker, kubernetes that will allow run multiple tasks parallelly build out dashboard which demonstrate and explain complex analytics on the optimisation progress & results in real time. the data is transmitted over websocket new product development (e.g. implementing more advance & novel machine learning algorithms with our scientist team from scratch) tech stack: our tech stack follows open standards. these are processed in microservices. our backend is written in python, java, and c++. we use kafka and rabbitmq subscriptions to facilitate real time communication between the different components and deliver analytics to the user in real time. the infrastructure is built using docker and kubernetes. interview process: the interview process will include an interview where we will walk you through a coding case study and an architecture case study. this is to test that your ability to synthesise, analyse and provide solutions is at the relevant level required for this role. requirements you have at least 5 years commercial experience in backend software development you have extensive experience in 2 programming languages (e.g. python, java, c++ etc) you have extensive experience in mentoring junior software developers on design patterns, development best practices and devops trade-offs you understand emerging web development models you have experienced with all ancillary technologies necessary for internet and big data distributed system applications: http, tcp/ip, websocket, kafka, rabbitmq, docker etc. you have experience designing and implementing high scalability projects involving cloud-based infrastructure you have experience debugging distributed systems with high data loads you have deep understanding of distributed data model you have solid understanding of the software as a service (saas) model in the online environment you have experience designing and delivering low latency, highly scalable complex systems which consume large amounts of data you have excellent communication skills with both engineering and business people to support and deliver cross departmental projects you can demonstrate a passion for technology and engineering through relevant extra curricular activities e.g. side projects, blogs, engagement with wider tech community. understand the machine learning algorithm you have experience on designing and implementing system based on cloud infrastructure on azure, google cloud and aws. you hold at least bachelor’s degree in computer science, a related field, or equivalent practical experience, and hold master or phd degree in computer science or a related field is a plus. benefits generous holiday allowance (28 days) - we encourage everyone to use their allowance! company pension scheme monthly team dinners annual company dinner central london location unlimited artisan coffee fresh fruits, nuts, beers and other snacks provided job type: full-time salary: £38,366.00-£81,928.00 per year additional pay: bonus scheme benefits: company events schedule: monday to friday education: master's (preferred) work remotely: no

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