Evonetix is a start-up company which is set to revolutionize de novo gene synthesis, as needed to facilitate the fast-growing and incredibly exciting field of synthetic biology. Our technology is based on a novel silicon array, manufactured with semiconductor microfabrication techniques and capable of the independent control of many thousands of miniaturized reaction sites, allowing massive parallelism of the DNA synthesis process. We have just closed our $30M Series B funding round and recently moved to a state-of-the-art facility in central Cambridge where we intend to undertake significant recruitment to enable the development of our commercial DNA synthesiser.
Our novel approach to DNA synthesis and assembly is set to revolutionise what is possible with a desktop DNA synthesiser. We are developing an enzymatic gene synthesis approach compatible with our platform. We are looking for a Protein Engineer to join the Biology team and contribute to the development of highly efficient enzymes to incorporate our proprietary modified nucleotides. You will work with the Enzymatic Synthesis Technical Lead and his/her team to plan and deliver an experimental programme to develop a new enzymatic DNA synthesis approach and its transfer toward an integrated process onto Evonetix’s platform. Job duties include, but are not limited to: • design and execute protein engineering strategies to develop new enzymes for enzymatic DNA synthesis. • design, develop and evaluate new assays for kinetic and stability characterisation of enzymes. • adapt and optimize existing workflows and develop new approaches to screen improved enzymes. • process transfer from early-stage research results to integrated technological development. • written and verbal communication of plans, procedures, and results. This is an exciting role at the cutting edge of biotechnology and synthetic biology. You will work with the Enzymatic Synthesis Technical Lead and be part of a closely knit multi-disciplinary team of chemists, physicists and engineers to exploit the unique features of a novel chip technology to create highly compatible gene synthesis and assembly methodologies.
Essential skills and experience
A successful candidate must fulfil the following requirements: • Ph.D. in Molecular Biology, Biochemical Engineering, Biophysics, or other relevant field in Biosciences. • High-level of knowledge and hands-on experience with molecular biology, biochemistry, and enzymology, including the generation of variant libraries, assay development, high-throughput screening and enzyme characterization, ideally in an industrial environment. • Proficiency/familiarity with analytical techniques (capillary electrophoresis, liquid chromatography, mass spectrometry) needed to evaluate enzyme performance would be an advantage. • Proficiency/familiarity with computational approaches related to protein engineering is desirable. • Understanding of product development would also be advantageous. • Excellent analytical and problem-solving skills with strong attention to detail. • Ability to work in a fast changing and developing environment that requires continual enhancement of knowledge and skills. • Ability to work independently but also in a large multi-disciplinary team and understand the technical constraints of all facets of the technology to effectively achieve integration of all components. • Excellent communication and interpersonal skills with senior management, collaborators and other personnel at all levels. • Good organisational skills to meet challenging development milestones. • Regular presentations of progress to management and colleagues. • Excellent writing skills.
This opportunity comes with an attractive benefits package which includes a contributory pension, private medical care, life assurance as well as the opportunity to partake in the staff equity scheme. « Return to the search results