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Search research fellow in structural molecular biology

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research fellow in structural molecular biology

Posted on: 15 May 2021

Employer:
University of Leeds
Salary:
£33,797 per year
Location:
leeds
Job Type:
Full-time
Visa:
Calculate Your PBS score for this Job

Research Fellow in Structural Molecular Biology


Are you an ambitious researcher looking for your next challenge?
Do you have an established background in structural molecular biology? Do you want to further your career in one of the UKs leading research-intensive Universities?


 We are looking for a highly motivated postdoctoral research fellow to join a team of researchers investigating the structural basis of hypertrophic cardiomyopathy, an inherited heart disease that affects more than 1 in 500 people. Most mutations resulting in disease are found in either β-cardiac myosin heavy chain or cardiac myosin-binding protein-C (cMyBP-C) yet the link between mutation and disease outcome is poorly characterised. By use of an integrative structural biology approach this research project will unravel structural-functional relationships between β-cardiac myosin and cMyBP-C and the impact of disease mutation on those relationships. The project will use a combination of electron microscopy (negative-stain and cryo), structural mass spectrometry, biochemistry, biophysics, molecular modelling and cell biology methods.


 You should have a PhD (or be close to completion) in Biology, Biochemistry, Biophysics or a related discipline. You should have experience in the analysis of protein structure, dynamics and protein-protein interactions using either structural mass spectrometry methods (e.g. native mass spectrometry, chemical crosslinking, covalent footprinting and/or hydrogen-deuterium exchange), and/or cryo-electron microscopy, and complementary biophysical methods (e.g. circular dichroism, SDS-PAGE). You should also have experience in protein production from bacterial and, insect or/and mammalian cells.


 You will be based in the laboratory of Dr Charlie Scarff (BHF Intermediate Fellow) and will work closely with collaborators at Leeds (Dr James Ault, Dr Sarah Harris and Prof. Michelle Peckham), across the UK and internationally (Prof. Howard White, EVMS and Prof. Donald Winkelmann, Rutgers). You will join the vibrant Astbury Centre community and benefit from the world-leading facilities we have in the Astbury Biostructure Laboratory (two Titan Krios microscopes) and Faculty of Biological Sciences (dedicated HDX-MS system, UHMR Q-Exactive and Orbitrap Exploris).


 To explore the post further or for any queries you may have, please contact:


 Doctor Charlie Scarff


 BHF Jacqueline Murray Coomber Fellow, Email: c.a.scarff@leeds.ac.uk


POINTS BASED SYSTEM (PBS) VISA CALCULATOR

Under the points-based immigration system, you are required to score a minimum of 70 points for your Skilled Worker visa application. You must satisfy all the mandatory rules that give you 50 points, and any of the additional tradeable rules. Read more about this system on gov.uk

Occupation Title: research fellow
SOC Code: 2119
Minimum Salary: £33,000.00

You automatically score 60/70 points with this job

Job at an appropriate skill level (RQF 3 or above).
Your job must meet the minimum skill level set by the UK government. A list of eligible occupations can be found at www.gov.uk
20 Mandatory
Job offered by a licensed sponsor.
A company must have a sponsorship licence to hire overseas employees. An official companies register is available at www.gov.uk
20 Mandatory
Salary of at least £25,600 or the going rate of the profession (whichever is higher).
There is a general salary threshold and a going rate set for each occupation. If the going rate for your job is higher than £25,600, you’ll usually need to be paid at least the going rate to earn 20 points.
20 Mandatory

How can you score additional points?

English language skills at level B1 (intermediate).
10 Mandatory

Do you qualify as a new entrant?

20 Tradeable
I’m working towards a recognised professional qualification or moving directly into postoctoral position
I’m switching from a UK Student or Graduate visa
I’m under the age of 26
None of the above

Do you hold a PhD qualification?

20 Tradeable
Yes, I have a Non-STEM PhD level qualification
None of the above

Your score is 60/70

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Please note that UKHIRED LTD is not registered to provide any immigration advice. Information on our website is taken from the public domain source and therefore might be inaccurate at times. We recommend you always check the official Skilled Worker guidelines available on gov.uk and seek help from a qualified immigration specialist. Our content does not constitute legal advice and is provided for general information purposes only.

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