Senior Research Scientist in Cellular Genomics Do you have experience with CRISPR and RNAi methodologies, and would you like to turn that into discovery of new pioneering drug candidates? Then you may be the new colleague that we would like to welcome to our team. About Novo Nordisk Research Centre Oxford (NNRCO)
Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. We employ more than 42,000 people in 80 countries and market our products in around 170 countries. Novo Nordisk Research Centre Oxford (NNRCO) is Novo Nordisk’s Translational Research Unit focused on biology and target discovery across the broad spectrum of cardiometabolic disease in Oxford, United Kingdom. Our location in the heart of the University of Oxford medical campus enables two-way collaborations with some of the best medical scientists in the world. We use genetics, functional genomics, human-centric disease models and computational biology to develop an unparalleled understanding of cardiometabolic disease and deliver therapies that transform the lives of patients.
You can read more about Novo Nordisk Research Centre Oxford at: http://www.novonordisk.co.uk/about-novo-nordisk-in-uk/oxford-research-centre.html About the Department The Department of Discovery Technologies and Genomics has as its mission to establish and apply state-of-the-art genomics and screening technologies to discover and validate novel therapeutic targets for cardiometabolic diseases using human-centric in vitro approaches. Ultimately, our aim is to identify targets and key biology to discover new disruptive therapeutics.
The department is led by Carina Ämmälä, and consists of specialists, staff scientists and post-doctoral scientists. We are a dedicated, collaborative team, working within a variety of advanced technologies, including high throughput screening, high content imaging, single-cell sequencing, CRISPR editing, functional genomics, proteomics, peptidomics, and statistical modelling. Together, we share a passion for translational research and a desire to discover new scientific paths to improve the lives of patients. The Position We offer you an inspiring position where you will be part of a cross-functional team in which scientific goals require contributions from many highly specialised colleagues. Your focus will be setting strategic direction and establishing state-of-the-art CRISPR and RNAi technologies to support our effort to discover novel transformational targets for cardiometabolic diseases. Your main responsibility is the development of qualitative and quantitative functional genomics in-vitro assays in human cell models relevant to cardiometabolic diseases, including optimization of assays for high-throughput, genome-wide screens in primary human cells. To succeed in this role, you will need to build and foster collaborations both externally and internally in the organisation. Internally, you will work with members in our computational biology department to develop and apply machine learning and large-scale data mining pipelines. Externally, you will need to establish academic collaborations and external networks in functional genomics. Furthermore, an important part of your responsibility will be to mentor more junior team members in CRISPR and RNAi methodologies. Generation of new ideas for drug targets, promotion of project proposals as well as leading research projects in the cardiometabolic research area are expected contributions.
Qualifications The ideal candidate has a PhD in Systems biology, Transcriptomics, Bioinformatics, single cell RNA seq or a related field with extensive and documented hands on experience of CRISPR and other state-of-the-art functional genomics methods, either from biotech/industry or post-doctoral positions. Experience in computational biology, epigenomics, advanced statistics and/or machine learning as well as general understanding of cardiometabolic disorders and drug discovery is considered a plus. To be successful in this position, you must have an entrepreneurial mind-set, superior problem-solving skills and the ability to understand complex biological systems. You must be a team player and self-starter and be strongly motivated to explore new ideas and methods in order to drive innovation for the benefit of our patients. Salary range indication: GBP 50.000-60.000 yearly Working at Novo Nordisk At Novo Nordisk, we use our skills, dedication and ambition to help people with diabetes. We offer the chance to be part of a truly global work place, where passion and engagement are met with opportunities for professional and personal development.
Contact For further information, please contact Carina Ämmälä on phone +44 782 460 6940